Objective To understand the status quo of acceptance of advanced care plan（ACP） for young and middle-aged cancer patients,and to analyze its influencing factors,so as to provide the basis for the implementation and promotion of ACP. Methods The convenience sampling method was adopted from September 2020 to February 2021 to investigate a total of 426 young and middle-aged cancer inpatients by a general information questionnaire,Patient’s Advance Care Planning Acceptance Questionnaire（ACPQ）,Wake Forest Physician Trust Scale（WFPTS） and Death Attitude Profile-Revised（DAP-R）. Multiple linear stepwise regression was used to analyze the influencing factors of ACP acceptance. Results The score of ACP acceptance of 426 young and middle-aged cancer patients was（66.30±9.32）. Religious belief,course of disease,degree of pain,medical trust,and death attitude were the influencing factors of ACP acceptance of this population（P<0.05）. Conclusion The acceptance of ACP in young and middle-aged cancer patients is at the upper-middle level and it is affected by many factors. Clinical medical staff should identify the relevant factors affecting the acceptance of ACP,take standardized measures to help patients correctly face the disease and death,and improve the acceptance of ACP. It is suggested to popularize ACP knowledge and try ACP for young and middle-aged cancer patients.